T-type Ca channel modulation by otilonium bromide
نویسندگان
چکیده
Peter R. Strege, Lei Sha, Arthur Beyder, Cheryl E. Bernard, Edward Perez-Reyes, Stefano Evangelista, Simon J. Gibbons, Joseph H. Szurszewski, and Gianrico Farrugia Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota; Department of Pharmacology, University of Virginia, Charlottesville, Virginia; and Department of Preclinical Development, Menarini Ricerche, Florence, Italy
منابع مشابه
T-type Ca(2+) channel modulation by otilonium bromide.
Antispasmodics are used clinically to treat a variety of gastrointestinal disorders by inhibition of smooth muscle contraction. The main pathway for smooth muscle Ca(2+) entry is through L-type channels; however, there is increasing evidence that T-type Ca(2+) channels also play a role in regulating contractility. Otilonium bromide, an antispasmodic, has previously been shown to inhibit L-type ...
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